Monster by A. Lee Martinez did just that when I laid eyes on it in an article on io9. I'm not sure who designed the cover, but kudos to them.
As for the story, Martinez's sixth novel follows the exploits of an exterminator of sorts. His brand of pest-control concentrates on rarer forms of creatures--mythical creatures, to be precise. Neat. The reviews I've read for this one have been a little mixed, but the premise sounds refreshing enough to make me want to give it a chance.
This sound like the kind of novel you could get into? Have you read it already? If so, what did you think?